Jun. Prof. Dr. Ingrid Span

Liebig Research Group Leader
Strukture and Function of Metalloproteins

Faculty of Mathematics and Natural Sciences

Contact:
Phone: 0211 81-15582
Email: undefinedingrid.span@hhu.de
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Academic Career and Research Areas

The Liebig research group of Jun. Prof. Dr. Ingrid Span is interested in proteins that require transition metal-containing cofactors for their catalytic function. The group uses structural biology, biochemistry, and biophysical methods to understand the molecular bases of living processes. The incorporation of cofactors such as metal ions or metal clusters into the active site of proteins leads to exiting chemistry with incredible specificity.

Jun. Prof. Dr. Ingrid Span studied chemistry at Technical University of Munich (TUM) and also obtained her PhD from TUM in 2012. She continued her research as a Postdoc at Northwestern University in Chicago, USA. Since 2014 she is doing research at Heinrich Heine University (HHU). In 2015 she became Liebig research group leader. Since the beginning of 2017 she has been an assistant professor in biology at HHU.

Distinctions and Awards
  • since 2017 member of AcademiaNet
  • Junior professorship funded by Landesprogramm für geschlechtergerechte Hochschulen NRW
  • Liebig Fellowship of Funds of the Chemical Industry (FCI)
  • Research Fellowship of the German Research Foundation (DFG)
  • Emil Erlenmeyer Medal
  • PhD Prize of the Association of Friends of the Technical University Munich, Germany
Key publications

Charge-Disproportionation Symmetry Breaking Creates a Heterodimeric Myoglobin Complex with Enhanced Affinity and Rapid Intracomplex Electron Transfer. E. N. Trana, J. M. Nocek, J. V. Woude, I. Span, S. M Smith, A. C. Rosenzweig, B. M. Hoffman, J. Am. Chem. Soc. 2016, 138 (38), 12615–12628.

A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. S. G. Kathman, I. Span, A. T. Smith, Z. Xu, J. Zhan, A. C. Rosenzweig, A. V. Statsyuk, J. Am. Chem. Soc. 2015, 137 (39), 12442-12445.

Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH. I. Span, K. Wang, W. Eisenreich, A. Bacher, Y. Zhang, E. Oldfield, M. Groll, J. Am. Chem. Soc. 2014, 136 (22), 7926-7932.

Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH. I. Span, K. Wang, W. Wang, J. Jauch, W. Eisenreich, A. Bacher, E. Oldfield, M. Groll, Angew. Chem. 2013, 125 (7), 2172-2175.

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH. I. Span, K. Wang, W. Wang, Y. Zhang, A. Bacher, W. Eisenreich, K. Li, C. Schulz, E. Oldfield, M. Groll, Nat. Commun. 2012, 3, 1042.

 

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