Dr. Manuel Etzkorn

Emmy Noether Research Group
Time-optimized NMR spectroscopy for the investigation of challenging biological systems

Faculty of Mathematics and Natural Sciences

Contact:
Phone: 0211 81-12023
Email: undefinedmanuel.etzkorn@hhu.de
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Academic Career and Research Areas

The Emmy Noether Research Group of Dr. Manuel Etzkorn aims to identify and apply the most suitable technique and (membrane) environment in order to understand complex biological systems. Therefore they are using on the one hand well-established test proteins such as bacteriorhodopsin to explore feasibilities and limitations of promising non-conventional tools such as nanodiscs and amphipathic polymers. On the other hand they make use of the obtained information to advance the characterization of more challenging and pharmacologically relevant membrane proteins. For the latter they are in particular interested in understanding the molecular mechanism involved in hormone-receptor interactions. 

Dr. Manuel Etzkorn studied physics at the University of Göttingen, where he recieved his diploma in 2004. Subsequently he did his doctoral studies at the Max Planck Institute for Biophysical Chemistry in Göttingen. From 2009 to 2012 he worked as a Postdoc at Harvard Medical School in Boston, USA and at MIT/Harvard Center of Magnetic Resonance in Cambridge, USA. Since 2013 he is a Emmy Noether research group leader at HHU and Forschungszentrum Jülich.

Distinctions and Awards
  • Felix Bloch Lecture of the German Chemical Society, 2018
  • Ulrich-Hadding-Research Award of the "Biological-Medical Research Center (BMFZ)" at HHU, 2017
  • Group leader in the Emmy Noether Program of the German Research Foundation (DFG), since 2013
  • DAAD Research Fellowship 2009-2011

Key publications

Viegas A, Viennet T, Etzkorn M: The power, pitfalls and potential of the nanodisc system for NMR-based studies Biol. Chem. (2016)

Viennet T, Viegas A, Kuepper A, Arens S, Gelev V, Petrov O, Grossmann TN, Heise H, Etzkorn M: Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization Angew. Chem. Int. Ed. 55, 10746-10750, (2016)

Viegas A, Viennet T, Yu TY, Schumann F, Bermel W, Wagner G, Etzkorn M: UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection. J. Biomol. NMR 64, 9-15, (2016)

Etzkorn M, Raschle T, Hagn F, Gelev V, Rice A, Walz T, Wagner G: Cell-Free Expressed Bacteriorhodopsin in Different Soluble Membrane Mimetics: Biophysical Properties and NMR Accessibility. Structure 21, 394-401 (2013)

Hagn F, Etzkorn M, Raschle T, Wagner G: Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins. J. Am. Chem. Soc. 135, 1919-1925 (2013)

Etzkorn M, Kneuper H, Dünnwald P, Vijaian V, Griesinger C, Becker S, Unden G, Baldus M: Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS. Nat. Struct. Mol. Biol. 15, 1031-1039 (2008)

Etzkorn M, Martell S, Andronesi OC, Seidel K, Engelhard M, Baldus M: Secondary structure and topology of a seven-helix receptor in native membranes studied by solid-state NMR. Angew. Chem. Int. Ed. 46, 459-462 (2007)

 

Photo: Hanne Horn

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